Publications | LUCASBIO

Cytokine-Induced Killer Cell Therapy as a Postremission Strategy in High-Risk Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Prospective Investigator-Initiated Clinical Study

Publication information: Transplant Cell Ther. 2026 Apr;32(4):448.e1-448.e16. doi: 10.1016/j.jtct.2026.01.001.

Authors: Gi-June Min, Nayoun Kim, Keon-Il Im, Junseok Lee, Taeyeon Kim, Dong Jip Kim, Seok-Goo Cho

Effectiveness and Safety of Autologous Virus-Specific T-Cell Therapy for Persistent COVID-19 in People With Immunocompromise: A Clinical Trial Study

Publication information: Clin Infect Dis. 2026 Feb 4;81(6):e510-e514. doi: 10.1093/cid/ciaf302.

Authors: Raeseok Lee, Nayoun Kim, Won-Bok Kim, Keon-Il Im, Dukhee Nho, Sung-Yeon Cho, Chulmin Park, Kyongmin Sarah Beck, GyeongHui Lee, Inkee Lee, Seok-Goo Cho, Dong-Gun Lee

SARS-CoV-2-Specific T-Cell as a Potent Therapeutic Strategy against Immune Evasion of Emerging COVID-19 Variants

Publication information: Int J Mol Sci . 2024 Sep 29;25(19):10512.

Authors: Keon-Il Im, Nayoun Kim, Junseok Lee, Ui-Hyeon Oh, Hye-Won Lee, Dong-Gun Lee, Gi-June Min, Raeseok Lee, Jinah Lee, Seungtaek Kim, Seok-Goo Cho

Repeated Infusions of Bone-Marrow-Derived Mesenchymal Stem Cells over 8 Weeks for Steroid-Refractory Chronic Graft-versus-Host Disease: A Prospective, Phase I/II Clinical Study

Publication information: Int J Mol Sci. 2024 Jun 19; 25(12): 6731

Authors: Nayoun Kim, Gi-June Min, Keon-Il Im, Young-Sun Nam, Yunejin Song, Jun-Seok Lee, Eun-Jee Oh, Nack-Gyun Chung, Young-Woo Jeon, Jong Wook Lee, Seok-Goo Cho

Mesenchymal Stem Cells Preconditioned with a TLR5 Agonist Enhanced Immunoregulatory Effect Through M2 Macrophage Polarization in a Murine Graft-versus-Host Disease Model

Publication information: Int J Med Sci. 2024 Jun 17; 21(9):1649-1660

Authors: Sojin Gil, Keon-Il Im, Nayoun Kim, Junseok Lee, Hyemin Na, Gi-June Min, Seok-Goo Cho

The IL-6 Signaling Pathway Contributes Critically to the Immunomodulatory Mechanism of Human Decidua-Derived Mesenchymal Stromal Cells

Publication information: iScience. 2024 Apr 18; 27(5): 109783

Authors: Hyemin Na, Keon-Il Im, Nayoun Kim, Junseok Lee, Sojin Gil, Gi-June Min, Seok-Goo Cho

TLR5 Agonist in Combination with Anti-PD-1 Treatment Enhances Anti-Tumor Effect Through M1/M2 Macrophage Polarization Shift and CD8+ T Cell Priming

Publication information: Cancer Immunol Immunother . 2024 Apr 17;73(6):102.

Authors: Junseok Lee, Keon-Il Im, Sojin Gil, Hyemin Na, Gi-June Min, Nayoun Kim, Seok-Goo Cho

Off-the-Shelf Partial HLA Matching SARS-CoV-2 Antigen Specific T Cell Therapy: A New Possibility for COVID-19 Treatment

Publication information: Front. Immunol., 23 December 2021

Authors: Nayoun Kim, Jong-Min Lee, Eun-Jee Oh, Dong Wook Jekarl, Dong-Gun Lee, Keon-Il Im, Seok-Goo Cho

Human Mesenchymal Stem Cells Derived From Umbilical Cord and Bone Marrow Exert Immunomodulatory Effects in Different Mechanisms

Publication information: World J Stem Cells. 2020 Sep 26;12(9):1032-1049.

Authors: Yunejin Song, Jung-Yeon Lim, Taekyu Lim, Keon-Il Im, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Jong Chul Shin, Hyun Sun Ko, In Yang Park, Seok-Goo Cho

Enhancement of Graft-Versus-Host Disease Control Efficacy by Adoptive Transfer of Type 1 Regulatory T Cells in Bone Marrow Transplant Model.

Publication information: Stem Cells Dev. 2019 Jan 15;28(2):129-140.

Authors: Young-Woo Jeon, Jung-Yeon Lim, Keon-Il Im, Nayoun Kim, Young-Sun Nam, Yun-Jin Song, Seok-Goo Cho

Infusions of Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes as Post-Remission Therapy in High-Risk Post-Transplant Lymphoproliferative Disorder Patients: Report of Two Cases.

Publication information: Int J Hematol. 2018 May;107(5):596-603.

Authors: Nayoun Kim, Hyun-Jung Sohn, Joo Hyun Oh, Young-Woo Jeon, Hyun-Joo Lee, Hyun-Il Cho, Byung Ha Chung, Chul-Woo Yang, Tai-Gyu Kim, Seok-Goo Cho

Robust Production of Cytomegalovirus PP65-Specific T cells Using a Fully Automated IFN-g Cytokine Capture System.

Publication information: Transfus Med Hemother. 2018 Jan;45(1):13-22.

Authors: Nayoun Kim, Young-Sun Nam, Keon-Il Im, Jung-Yeon Lim, Young-Woo Jeon, Yunejin Song, Jong Wook Lee, Seok-Goo Cho

Third-Party Regulatory T Cells Prevent Murine Acute Graft-versus-Host Disease.

Publication information: Korean J Intern Med. 2017 Oct 19. doi: 10.3904/kjim.2016.319

Authors: Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho

Alternative Approaches to Preserve MSC Progenitor Potency.

Publication information: Blood Res. 2017 Mar;52(1):1-2. doi: 10.5045/br.2017.52.1.1. Epub 2017 Mar 27.

Authors: Nayoun Kim, Ph.D., Seok-Goo Cho, M.D., Ph.D.

Enhanced Immunoregulation of Mesenchymal Stem Cells by IL-10-Producing Type 1 Regulatory T Cells in Collagen-Induced Arthritis.

Publication information: Scientific reports 2016;6:2685

Authors: Jung-Yeon Lim, Keon-Il Im, Eun-Sol Lee, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho

Therapeutic Potential of Low-Dose IL-2 in a Chronic GVHD Patient by In Vivo Expansion of Regulatory T Cells.

Publication information: Cytokine 2016;78:22-26.

Authors: Nayoun Kim, Young-Woo Jeon, Young-Sun Nam, Jung-Yeon Lim, Keon-Il Im, Eun-Sol Lee, Seok-Goo Cho

Overcoming Immunoregulatory Plasticity of Mesenchymal Stem Cells for Accelerated Clinical Applications.

Publication information: International journal of hematology 2016;103:129-137.

Authors: Nayoun Kim, Seok-Goo Cho

Il-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma Through Efficient Delivery of IL-21, Which Redirects the Immune System to Target the Tumor.

Publication information: Stem cells and development 2015;24:2808-2821.

Authors: Nayoun Kim, Young-Sun Nam, Keon-Il Im, Jung-Yeon Lim, Eun-Sol Lee, Young-Woo Jeon, Seok-Goo Cho

Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD model.

Publication information: PloS one 2015;10:e0138846.

Authors: Eun-Sol Lee, Jung-Yeon Lim, Keon-Il Im, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho

Long-Term Outcome of Extranodal NK/T Cell Lymphoma Patients Treated with Post-Remission Therapy Using EBV LMP1 and LMP2a-Specific CTLs.

Publication information: Molecular therapy : the journal of the American Society of Gene Therapy 2015;23:1401-1409.

Authors: Seok-Goo Cho, Nayoun Kim, Hyun-Jung Sohn, Suk Kyeong Lee, Sang Taek Oh, Hyun-Joo Lee, Hyun-Il Cho, Hyeon Woo Yim, Seung Eun Jung, Gyeongsin Park, Joo Hyun Oh, Byung-Ock Choi, Sung Won Kim, Soo Whan Kim, Nak Gyun Chung, Jong Wook Lee, Young Seon Hong, Tai-Gyu Kim

Publications | LUCASBIO

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Pipeline & Science

Cytokine-Induced Killer Cell Therapy as a Postremission Strategy in High-Risk Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Prospective Investigator-Initiated Clinical Study

Effectiveness and Safety of Autologous Virus-Specific T-Cell Therapy for Persistent COVID-19 in People With Immunocompromise: A Clinical Trial Study

SARS-CoV-2-Specific T-Cell as a Potent Therapeutic Strategy against Immune Evasion of Emerging COVID-19 Variants

Repeated Infusions of Bone-Marrow-Derived Mesenchymal Stem Cells over 8 Weeks for Steroid-Refractory Chronic Graft-versus-Host Disease: A Prospective, Phase I/II Clinical Study

Mesenchymal Stem Cells Preconditioned with a TLR5 Agonist Enhanced Immunoregulatory Effect Through M2 Macrophage Polarization in a Murine Graft-versus-Host Disease Model

The IL-6 Signaling Pathway Contributes Critically to the Immunomodulatory Mechanism of Human Decidua-Derived Mesenchymal Stromal Cells

TLR5 Agonist in Combination with Anti-PD-1 Treatment Enhances Anti-Tumor Effect Through M1/M2 Macrophage Polarization Shift and CD8+ T Cell Priming

Off-the-Shelf Partial HLA Matching SARS-CoV-2 Antigen Specific T Cell Therapy: A New Possibility for COVID-19 Treatment

Human Mesenchymal Stem Cells Derived From Umbilical Cord and Bone Marrow Exert Immunomodulatory Effects in Different Mechanisms

Enhancement of Graft-Versus-Host Disease Control Efficacy by Adoptive Transfer of Type 1 Regulatory T Cells in Bone Marrow Transplant Model.

Infusions of Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes as Post-Remission Therapy in High-Risk Post-Transplant Lymphoproliferative Disorder Patients: Report of Two Cases.

Robust Production of Cytomegalovirus PP65-Specific T cells Using a Fully Automated IFN-g Cytokine Capture System.

Third-Party Regulatory T Cells Prevent Murine Acute Graft-versus-Host Disease.

Alternative Approaches to Preserve MSC Progenitor Potency.

Enhanced Immunoregulation of Mesenchymal Stem Cells by IL-10-Producing Type 1 Regulatory T Cells in Collagen-Induced Arthritis.

Therapeutic Potential of Low-Dose IL-2 in a Chronic GVHD Patient by In Vivo Expansion of Regulatory T Cells.

Overcoming Immunoregulatory Plasticity of Mesenchymal Stem Cells for Accelerated Clinical Applications.

Il-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma Through Efficient Delivery of IL-21, Which Redirects the Immune System to Target the Tumor.

Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD model.

Long-Term Outcome of Extranodal NK/T Cell Lymphoma Patients Treated with Post-Remission Therapy Using EBV LMP1 and LMP2a-Specific CTLs.

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